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pentobarbital will lessen the extent or influence of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the level or outcome of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma